Evidencias de respuesta inmune pro-inflamatoria en la SQM

[elipoarch]

Por fin buenas notícias para los enfermos de Sensibilidad Química Múltiple. Este equipo danés ha comparado los niveles de citokinas en el plasma sanguíneo de enfermos de SQM con el las de controles sanos y han llegado a una conclusión interesante: "Los enfermos de SQM mostraron un perfil inmunológico propio, con niveles elevados de citokinas pro-inflamatorias y niveles inversos en otras, lo que sugiere una inflamación sistémica de grado bajo"

[t]An elevated pro-inflammatory cytokine profile in multiple chemical sensitivity[/t]
T.M. Dantofta, J. Elberlinga, S. Brixb, P.B. Szecsic, S. Vesterhauged, S. Skovbjerga
a The Danish Research Centre for Chemical Sensitivities, Department of Dermato-Allergology, Copenhagen University Hospital Gentofte, Gentofte, Denmark
b Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
c Department of Clinical Biochemistry, Copenhagen University Hospital Gentofte, Gentofte, Denmark
d Aleris-Hamlet, Private Hospital, Copenhagen, Denmark


Abstract
Background
Multiple chemical sensitivity (MCS) is a medically unexplained condition characterized by reports of recurrent unspecific symptoms attributed to exposure to low levels of common volatile chemicals. The etiology of MCS is poorly understood, but dysregulation of the immune system has been proposed as part of the pathophysiology.

Objective
To compare plasma levels of cytokines in Danish MCS individuals with a healthy, sex- and age-matched control group.

Method
Blood samples were obtained from 150 un-exposed MCS individuals and from 148 age- and sex-matched healthy controls. Plasma concentrations of 14 cytokines, chemokines and growth and allergen-specific IgE were measured. All participants completed a questionnaire including questions on MCS, psychological distress, morbidities and medication use at the time of the study.

Results
Plasma levels of interleukin-1β, -2, -4, and -6 were significantly (P <0.001) increased in the MCS group compared with controls, tumor necrosis factor-α was borderline significantly (p = 0.05) increased and interleukin-13 was significantly decreased.

Conclusion
MCS individuals displayed a distinct systemic immune mediator profile with increased levels of pro-inflammatory cytokines and interleukin-2 and inverse regulation of Th2 associated cytokines interleukin-4 and interleukin-13 suggestive of low-grade systemic inflammation, along with a deviating Th2-associated cytokine response not involving IgE-mediated mechanisms.

enlace: http://www.sciencedirect.com/science/ar ... 3013004289" onclick="window.open(this.href);return false;

[tranqui]

Nótese que la observacion de "increased levels of pro-inflammatory cytokines ... suggestive of low-grade systemic inflammation" está totalmente en línea con la teoria de Pall, que describe no solamente el SFC sino tambien la fibromialgia y la SQM, cada uno con sus caracteristicas propias.

http://thetenthparadigm.org/mcs09.htm

[María José]

Qué buenas noticias. Con las pocas alegrías que tenemos, que toque alguna ya era hora, jeje.
Muchas gracias por poner el estudio, Eli. Voy a leérmelo.
¡Un abrazo!