La conectividad cerebral como biomarcador de la Fibromialgia
Publicado: 01 Jul 2012, 01:55
La actividad cerebral en reposo y su conectividad reflejan el dolor en la Fibromialgia - Un estudio con un nuevo enfoque en el que, mediante Resonancia Magnética, se mide la actividad cerebral en reposo y la conectividad cerebral ha demostrado ser una medida objetiva del dolor en los pacientes con fibromialgia, según los firmantes del estudio. Es un estudio pequeño, pero prometedor. Al parecer, tras una intervención no farmacológica para reducir el dolor, se pudo demostrar que la reducción de la conectividad del cerebro en reposo coincidía con la reducción del dolor, y viceversa.
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[t]Decreased intrinsic brain connectivity is associated with reduced clinical pain in fibromyalgia[/t]
Vitaly Napadow1,*, Jieun Kim2, Daniel J. Clauw3,‡, Richard E. Harris3,§
Article first published online: 26 JUN 2012
DOI: 10.1002/art.34412
Copyright © 2012 by the American College of Rheumatology
Abstract
Objective
A major impediment to the development of novel treatment strategies for fibromyalgia (FM) is the lack of an objective marker that reflects spontaneously reported clinical pain in patients with FM. Studies of resting-state intrinsic brain connectivity in FM have demonstrated increased insular connectivity to the default mode network (DMN), a network whose activity is increased during nontask states. Moreover, increased insular connectivity to the DMN was associated with increased spontaneous pain levels. However, as these analyses were cross-sectional in nature, they provided no insight into dynamic changes in connectivity or their relationship to variations in self-reported clinical pain. The purpose of this study was to evaluate longitudinal changes in the intrinsic brain connectivity of FM patients treated with nonpharmacologic interventions known to modulate pain levels in this patient population, and to test the hypothesis that the reduction of DMN–insula connectivity following therapy would correlate with diminished pain.
Methods
Seventeen FM patients underwent resting-state functional magnetic resonance imaging at baseline and following 4 weeks of a nonpharmacologic intervention to diminish pain. Intrinsic DMN connectivity was evaluated using probabilistic independent components analysis. Longitudinal changes in intrinsic DMN connectivity were evaluated by paired analysis, and correlations between longitudinal changes in clinical pain and changes in intrinsic DMN connectivity were investigated by multiple linear regression analysis. Changes in clinical pain were assessed with the short form of the McGill Pain Questionnaire (SF-MPQ).
Results
Clinical pain as assessed using the sensory scale of the SF-MPQ was reduced following therapy (P = 0.02). Intrinsic DMN connectivity to the insula was reduced, and this reduction correlated with reductions in pain (corrected P < 0.05).
Conclusion
Our findings suggest that intrinsic brain connectivity can be used as a candidate objective marker that reflects changes in spontaneous chronic pain within individual FM patients. We propose that intrinsic connectivity measures could potentially be used in either research or clinical settings as a complementary, more objective outcome measure for use in FM.
enlace: http://onlinelibrary.wiley.com/doi/10.1 ... 2/abstract" onclick="window.open(this.href);return false;
______________
[t]Decreased intrinsic brain connectivity is associated with reduced clinical pain in fibromyalgia[/t]
Vitaly Napadow1,*, Jieun Kim2, Daniel J. Clauw3,‡, Richard E. Harris3,§
Article first published online: 26 JUN 2012
DOI: 10.1002/art.34412
Copyright © 2012 by the American College of Rheumatology
Abstract
Objective
A major impediment to the development of novel treatment strategies for fibromyalgia (FM) is the lack of an objective marker that reflects spontaneously reported clinical pain in patients with FM. Studies of resting-state intrinsic brain connectivity in FM have demonstrated increased insular connectivity to the default mode network (DMN), a network whose activity is increased during nontask states. Moreover, increased insular connectivity to the DMN was associated with increased spontaneous pain levels. However, as these analyses were cross-sectional in nature, they provided no insight into dynamic changes in connectivity or their relationship to variations in self-reported clinical pain. The purpose of this study was to evaluate longitudinal changes in the intrinsic brain connectivity of FM patients treated with nonpharmacologic interventions known to modulate pain levels in this patient population, and to test the hypothesis that the reduction of DMN–insula connectivity following therapy would correlate with diminished pain.
Methods
Seventeen FM patients underwent resting-state functional magnetic resonance imaging at baseline and following 4 weeks of a nonpharmacologic intervention to diminish pain. Intrinsic DMN connectivity was evaluated using probabilistic independent components analysis. Longitudinal changes in intrinsic DMN connectivity were evaluated by paired analysis, and correlations between longitudinal changes in clinical pain and changes in intrinsic DMN connectivity were investigated by multiple linear regression analysis. Changes in clinical pain were assessed with the short form of the McGill Pain Questionnaire (SF-MPQ).
Results
Clinical pain as assessed using the sensory scale of the SF-MPQ was reduced following therapy (P = 0.02). Intrinsic DMN connectivity to the insula was reduced, and this reduction correlated with reductions in pain (corrected P < 0.05).
Conclusion
Our findings suggest that intrinsic brain connectivity can be used as a candidate objective marker that reflects changes in spontaneous chronic pain within individual FM patients. We propose that intrinsic connectivity measures could potentially be used in either research or clinical settings as a complementary, more objective outcome measure for use in FM.
enlace: http://onlinelibrary.wiley.com/doi/10.1 ... 2/abstract" onclick="window.open(this.href);return false;
