SFC/EM Investigación

Antiretrovirals and diastolic dysfunction

Hi, all.

Here's something to consider in connection with use of antiretroviral therapy in cases of ME/CFS.

As you probably know, Dr. Cheney has found that most of his ME/CFS patients have diastolic dysfunction of the heart.

Diastolic dysfunction is caused by a low rate of production of ATP by the mitochondria.

Dr. John McLaren Howard's testing at Acumen Lab in the UK commonly finds that ATP levels are low in people with ME/CFS due to mitochondrial dysfunction.

I think that all of this is consistent.

O.K., it's known that some of the antiretrovirals can cause mitochondrial problems. AZT is one that is reported to do this.

This raises the question as to whether antiretroviral therapy would interact with existing diastolic dysfunction to cause more serious heart-related problems in ME/CFS patients. I don't know the answer to this, but check out this abstract:

http://thomasland.metapress.com/cont...30150745q64h8/" onclick="window.open(this.href);return false;

This paper reports a high rate of diastolic dysfunction in HIV-infected patients. These patients are apparently on antiretroviral treatment. The abstract mentions that there is an increased risk of cardiovascular disease for HIV-positive patients who are managed on antiretroviral treatment. This study found a high rate of diastolic dysfunction in these patients.

The abstract does not say that the diastolic dysfunction was caused by the antiretrovirals, but given that some of the antiretroviral drugs are known to affect the mitochondria, I think this is something to be concerned about and to explore further.

Perhaps some of the antiretrovirals that have been found to be effective in vitro against the CFS-associated retroviruses do not impact the mitochondria in a deleterious manner. I don't know much about the antiretrovirals. Perhaps others here have information about this.

Best regards,

Rich

Me cuesta muchísimo entender el inglés así que ya me lo miraré con detenimiento.
Yo creo que ANTES de nada deberían "repararnos" el corazón y eso con las células madre se hace(hay abundantes estudios al respecto, de hecho es uno de los órganos más agradecidos y de los que más estudios se tienen).
A ver si termina de despegar lo de las células madre uterinas y nos curan a todas.
Les cuesta pero creo que ya están empezando con el despegue.

Además, coincide con las afirmaciones de mi hija, jajajaja, hace un par de meses o 3 me dijo que tenía el corazón malito pero que los médicos me lo iban a curar y luego ya me pondría bien(yo jamás hablé decorazón ni nada de eso con ella). ¡Es más listaaaaaaaaaaaaaaaaaaaaaaaaaaa!.
Los doc matándose a estudios para descubrir las disfunciones mitocondriales y demás y va mi niña y ¡zas!.