Alteración de la distribución de linfocitos en SFC
Publicado: 23 Jul 2014, 23:40
Un nuevo estudio inmunológico sobre Síndrome de Fatiga Crónica. Hace unos días que tenía pendiente colgarlo... En este estudio se pretende definir las deficiencias inmunológicas de los pacientes con SFC con la esperanza de mejorar su calidad de vida mediante tratamientos para mejorar su sistema inmunológico. En el resultado, afirman haber encontrado un significativo aumento de diversos linfocitos T y NK en los enfermos de Síndrome de Fatiga Crónica, con un porcentage de estos linfocitos respecto al total que puede llegar hasta un 30%, cuando la proporción total normal suele ser entre un 1% y un 5%, lo que interpretan como una demostración de que hay una alteración inmunitaria en estos pacientes, especialmente la respuesta inmune a infecciones virales crónicas. Concluye que hace falta más estudios en estos mismos pacientes para determinar si estos porcentajes son persistentes y si existe citotoxicidad respecto a las células infectadas por virus.
(bueno, no estoy muy fina últimamente, así que si mi interpretación no es totalmente correcta, que alguien me corrija, por favor)
Desde luego, como alguien que llegó al SFC tras un linfoma, me resulta muy interesante...
[t]Altered Distribution of Lymphocyte Populations in Chronic Fatigue Syndrome Patients[/t]
Authors: Isabel Barao, Ph.D., Daniel Peterson, M.D., Dorothy Hudig, Ph.D
Institutional Affiliations: University of Nevada, Reno, School of Medicine, Simmaron Research, Inc., Sierra Internal Medicine
Key Words: CFS, NK cells, T cells, cytotoxicity, viral infections
Objective: The goal of our research is to define immunologic deficiencies of patients with chronic fatigue syndrome (CFS) and ultimately to improve the health of these patients by increasing their immunity.
Setting: CFS is a debilitating disease of unknown cause(s) defined by the Centers for Disease Control and Prevention (CDC) in Atlanta, GA. Our patient population is the well-known Reno-Lake Tahoe CFS cohort.
Methods: Peripheral blood is the site of traffic of lymphocytes with varying roles in immunity. Lymphocytes are circulating so as to be available to fight infections anywhere in the body or trafficking into secondary lymphoid organs where the lymphocytes will proliferate and differentiate.There are different types of lymphocytes in the blood [including helper T cells, cytotoxic T cells, T cells, B cells, natural killer (NK), and NK-T cells]. Alterations in these populations from healthy individuals are a hallmark of immune stress. To profile these populations, we used flow cytometry with fluorescent antibodies to identify the different populations of lymphocytes in the peripheral blood of CFS patients.
Results: We found unusual increases in a 'hybrid' population of lymphocytes in CFS patients. This population has features of both T cells and NK cells and is normally 1-5% of all lymphocytes but can be as high as 30% in the CFS patients.
Interpretation: The results are consistent with altered immunity in CFS patients, particularly altered immune responses to chronic viral infections. Further characterization, including repeated tests of the same patients, is needed to determine if this unusual population is persistent and to determine if it can mediate cytotoxicity towards virally infected cells.
enlace: http://ctrin.unlv.edu/usb/abstracts/abstract_barao.html" onclick="window.open(this.href);return false;
(bueno, no estoy muy fina últimamente, así que si mi interpretación no es totalmente correcta, que alguien me corrija, por favor)
Desde luego, como alguien que llegó al SFC tras un linfoma, me resulta muy interesante...
[t]Altered Distribution of Lymphocyte Populations in Chronic Fatigue Syndrome Patients[/t]
Authors: Isabel Barao, Ph.D., Daniel Peterson, M.D., Dorothy Hudig, Ph.D
Institutional Affiliations: University of Nevada, Reno, School of Medicine, Simmaron Research, Inc., Sierra Internal Medicine
Key Words: CFS, NK cells, T cells, cytotoxicity, viral infections
Objective: The goal of our research is to define immunologic deficiencies of patients with chronic fatigue syndrome (CFS) and ultimately to improve the health of these patients by increasing their immunity.
Setting: CFS is a debilitating disease of unknown cause(s) defined by the Centers for Disease Control and Prevention (CDC) in Atlanta, GA. Our patient population is the well-known Reno-Lake Tahoe CFS cohort.
Methods: Peripheral blood is the site of traffic of lymphocytes with varying roles in immunity. Lymphocytes are circulating so as to be available to fight infections anywhere in the body or trafficking into secondary lymphoid organs where the lymphocytes will proliferate and differentiate.There are different types of lymphocytes in the blood [including helper T cells, cytotoxic T cells, T cells, B cells, natural killer (NK), and NK-T cells]. Alterations in these populations from healthy individuals are a hallmark of immune stress. To profile these populations, we used flow cytometry with fluorescent antibodies to identify the different populations of lymphocytes in the peripheral blood of CFS patients.
Results: We found unusual increases in a 'hybrid' population of lymphocytes in CFS patients. This population has features of both T cells and NK cells and is normally 1-5% of all lymphocytes but can be as high as 30% in the CFS patients.
Interpretation: The results are consistent with altered immunity in CFS patients, particularly altered immune responses to chronic viral infections. Further characterization, including repeated tests of the same patients, is needed to determine if this unusual population is persistent and to determine if it can mediate cytotoxicity towards virally infected cells.
enlace: http://ctrin.unlv.edu/usb/abstracts/abstract_barao.html" onclick="window.open(this.href);return false;
Será bueno buscar ayuda por ese lado??