Resultados preliminares con la LDN(Congreso en Glasgow)
Publicado: 25 Abr 2010, 18:56
Today was the European LDN Conference in Glasgow, Ireland. Dr Jarred Younger
of Stanford University was unable to attend because of the airline's
shutdown, but he was plugged in with Skype. Here are the notes that LDNnow
reported on Twitter about his speech on Fibromyalgia, CFS/ME and Low Dose
Naltrexone:
Dr. Jarred Younger's research on Low dose Naltrexone for CFS/ME being
unveiled at 2 pm exclusively.
Jarred Younger PhD, Rebecca McCue BS, Sean Mackey, MD, PhD-Fibromyalgia and
Low Dose Naltrexone.
Preliminary results on Low dose Naltrexone for FM funded by Jim and Connie
Binns and AFSA (American Fibromyalgia Syndrome Association) .
5% US women, 9 women to 1 man diagnosed with fibromyalgia. Muscular pain,
fatigue and insomnia are main symptoms as are joint pain and headaches. 18
tender points, 11 are painful. Diagnosis difficult. Controversial condition.
Microglia cells appear to play a role in Fibromyalgia. Produce TNF, IL-6,
Nitric Oxide and others. When ill with flu, microglia cells are what
produces ill feeling, tiredness and need to go to bed - useful for illness.
In fibromyalgia, microglia perform this role when no illness/hypersensit ive
to normal situations in body. No existing drug modulates microglia, but
compounds exist which can do this. NIH research on this. See Linda Watkins
research on microglia and low dose naltrexone. Theory - low dose naltrexone
binds to hyper-sensitive receptors on microglia.
New study - 30 women, mean age 43, no opiods, at least 6/10 on pain scale.
70% of fibromyalgia patients had improvement and 50% much or very much
improved on low dose naltrexone (50%-75% pain reduced). 30% who had no
improvement - ties in with 1st study, so consistent. 15% reduction in pain
from placebo, additional 15% reduction due to low dose naltrexone. It seems
that improvement persists to some extent even after low dose naltrexone
withdrawn. Vivid dreams side-effect - 20% on placebo, 47% on LDN. Seldom
disturbing dreams and tends to fade. 1 person dropped out of study (Judy-
this would be Tamra because of severe problems with a fungus infection) and
1 person reduced dose from 4.5 to 3mg and did well on that.
Next steps - Further analyses, long-term safety, mechanistic proof,
optimization. Researchers looking at levo-naltrexone and dextro-naltrexone
(Left and Right parts of molecule) to optimize. Des from Fibromyalgia UK
'Very positive' on the new study results.
Dr Jarred Younger - low dose naltrexone and fibromyalgia fatigue data
mirrored the fatigue results very closely. Dosage was given 1 hour before
retiring. 1 or 2 persons switched to during day dosing due to sleep
problems.
Process of licensing levo and dextro naltrexone will take 'years'.
Personal report by a woman (Maija) with CFS/ME:
People with CFS/ME often have many other infections and diseases including
auto-immune disease. Adrenal and other endocrine issues are also common. She
first heard of LDN in 2004. Received prescription in 2007 from dr. who had
never heard of LDN. Improvement in CFS/ME fatigue within 24 hours. Much
improved in first week, fever reduced. Maija's Dr now treats many of his
patients with LDN. Improvements reported from 50-70% improvement.
Could only walk '50 m', now '3Km'. Pain killers every day, now 1 every 2
weeks. LDN most effective for CFS/ME, but other drugs can help too. "Don't
believe people who say there are no treatments for CFS/ME." Maija's book on
Amazon - http://bit.ly/" onclick="window.open(this.href);return false; coFtLV
Next up - Christine Fowler Chronic Fatigue Syndrome patient.
Christine on low dose naltrexone - Now active, back to work as normal and
much, much improved. Less tired.
After 12 years of CFS/ME, now on 1.75mg low dose naltrexone recommending
anyone try it, 'shouting from the rooftops'.
Negatives - Memory still less effective and still more stressed than before.
Dr Tom Gilhooly believes CCSVI may feed into fibromyalgia and CFS/MS too.
Chronic Cerebrospinal Venous Insufficiency - newly identified venous
condition. International Union of Phlebology 2009. IUoP voted that #CCSVI
was new condition. For more info on CCSVI speech, you can go to twitter /
LDNNow.
Judy H
To better health through knowledge
Started taking LDN (Low Dose Naltrexone) on 1/21/2009 for Fibromyalgia,
Hypothyroid, PCOS and Restless Legs
http://health" onclick="window.open(this.href);return false;. groups.yahoo. com/group/ LDNforFibro/
of Stanford University was unable to attend because of the airline's
shutdown, but he was plugged in with Skype. Here are the notes that LDNnow
reported on Twitter about his speech on Fibromyalgia, CFS/ME and Low Dose
Naltrexone:
Dr. Jarred Younger's research on Low dose Naltrexone for CFS/ME being
unveiled at 2 pm exclusively.
Jarred Younger PhD, Rebecca McCue BS, Sean Mackey, MD, PhD-Fibromyalgia and
Low Dose Naltrexone.
Preliminary results on Low dose Naltrexone for FM funded by Jim and Connie
Binns and AFSA (American Fibromyalgia Syndrome Association) .
5% US women, 9 women to 1 man diagnosed with fibromyalgia. Muscular pain,
fatigue and insomnia are main symptoms as are joint pain and headaches. 18
tender points, 11 are painful. Diagnosis difficult. Controversial condition.
Microglia cells appear to play a role in Fibromyalgia. Produce TNF, IL-6,
Nitric Oxide and others. When ill with flu, microglia cells are what
produces ill feeling, tiredness and need to go to bed - useful for illness.
In fibromyalgia, microglia perform this role when no illness/hypersensit ive
to normal situations in body. No existing drug modulates microglia, but
compounds exist which can do this. NIH research on this. See Linda Watkins
research on microglia and low dose naltrexone. Theory - low dose naltrexone
binds to hyper-sensitive receptors on microglia.
New study - 30 women, mean age 43, no opiods, at least 6/10 on pain scale.
70% of fibromyalgia patients had improvement and 50% much or very much
improved on low dose naltrexone (50%-75% pain reduced). 30% who had no
improvement - ties in with 1st study, so consistent. 15% reduction in pain
from placebo, additional 15% reduction due to low dose naltrexone. It seems
that improvement persists to some extent even after low dose naltrexone
withdrawn. Vivid dreams side-effect - 20% on placebo, 47% on LDN. Seldom
disturbing dreams and tends to fade. 1 person dropped out of study (Judy-
this would be Tamra because of severe problems with a fungus infection) and
1 person reduced dose from 4.5 to 3mg and did well on that.
Next steps - Further analyses, long-term safety, mechanistic proof,
optimization. Researchers looking at levo-naltrexone and dextro-naltrexone
(Left and Right parts of molecule) to optimize. Des from Fibromyalgia UK
'Very positive' on the new study results.
Dr Jarred Younger - low dose naltrexone and fibromyalgia fatigue data
mirrored the fatigue results very closely. Dosage was given 1 hour before
retiring. 1 or 2 persons switched to during day dosing due to sleep
problems.
Process of licensing levo and dextro naltrexone will take 'years'.
Personal report by a woman (Maija) with CFS/ME:
People with CFS/ME often have many other infections and diseases including
auto-immune disease. Adrenal and other endocrine issues are also common. She
first heard of LDN in 2004. Received prescription in 2007 from dr. who had
never heard of LDN. Improvement in CFS/ME fatigue within 24 hours. Much
improved in first week, fever reduced. Maija's Dr now treats many of his
patients with LDN. Improvements reported from 50-70% improvement.
Could only walk '50 m', now '3Km'. Pain killers every day, now 1 every 2
weeks. LDN most effective for CFS/ME, but other drugs can help too. "Don't
believe people who say there are no treatments for CFS/ME." Maija's book on
Amazon - http://bit.ly/" onclick="window.open(this.href);return false; coFtLV
Next up - Christine Fowler Chronic Fatigue Syndrome patient.
Christine on low dose naltrexone - Now active, back to work as normal and
much, much improved. Less tired.
After 12 years of CFS/ME, now on 1.75mg low dose naltrexone recommending
anyone try it, 'shouting from the rooftops'.
Negatives - Memory still less effective and still more stressed than before.
Dr Tom Gilhooly believes CCSVI may feed into fibromyalgia and CFS/MS too.
Chronic Cerebrospinal Venous Insufficiency - newly identified venous
condition. International Union of Phlebology 2009. IUoP voted that #CCSVI
was new condition. For more info on CCSVI speech, you can go to twitter /
LDNNow.
Judy H
To better health through knowledge
Started taking LDN (Low Dose Naltrexone) on 1/21/2009 for Fibromyalgia,
Hypothyroid, PCOS and Restless Legs
http://health" onclick="window.open(this.href);return false;. groups.yahoo. com/group/ LDNforFibro/